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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image26 January 2026 Vol. No. 15 ; Issue No.719
Publications

1. Bhandare MS, Nandy K, Parray AM, Pawar A, Padhy A, Menon V, Chopde A, Chaudhari V, Shrikhande SV (2026). Interplay of Post-Pancreatectomy Acute Pancreatitis, Postoperative Pancreatic Fistula, and Mortality after Pancreatoduodenectomy: Insights from a Comprehensive Cohort Study of 1594 Patients and Development of Predictive Nomograms. Journal of the American College of Surgeons.

2. Dhar A, Siva S, Tan VS, Mahadevan A, Bruynzeel A, Tang C, Cury F, Corkum M, Ali M, Zaorsky NG, Cheung P, Hannan R, Hudes R, Morgan S, Lo S, Murthy V, Correa RJM, Swaminath A (2026). International Radiosurgery Oncology Consortium of the Kidney (IROCK) contouring guidelines for renal cell carcinoma treated with stereotactic ablative radiotherapy. International Journal of Radiation Oncology, Biology, Physics.

Thesis
Tejashree Satish Mahaddalkar. 2025. Understanding the Molecular Mechanism of Therapy Resistance in Glioblastoma Using Preclinical Orthotopic Mouse Model. (LIFE09201704017) (Guide: Dr. Manoj Mahimkar)

Site of the Week

SMPDB (The Small Molecule Pathway Database) is an interactive, visual database containing more than 30 000 small molecule pathways found in humans only.

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Interesting Reads

van Haften FJ, van der Sluis TC, Hepp HS, Mülling N, Nadafi R, Sampadi B, van Duikeren S, Mostert JS, van der Sterre R, van Veelen PA, Heieis GA, Veerkamp DMB, Wesselink TH, Vleeshouwers W, Beijnes M, Pardieck IN, van Horssen ELF, de Groot AF, van der Ploeg M, Kroep JR, de Miranda NFCC, van der Zanden SY, Neefjes J, Mei H, Vertegaal ACO, Everts B, van der Burg SH, Arens R (2026). Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling. Nature Immunology.

Video of the Week
Clinical Application of Genomics for Childhood Cancer Patients An Update
Upcoming Events
XXIV ANNUAL CONFERENCE Evidence Based Management of Cancers in India 2026

February 27th, 2026 to March 1st 2026

At Tata Memorial Hospital, Prof. R. D. Choksi Auditorium, Parel, Mumbai

National Cancer Grid (NCG) Advanced Tracheostomy Course: Multidisciplinary Inter professional Approach

February 21-22, 2026

At Prof RD Choksi Auditorium, Tata Memorial Hospital, Mumbai

1st International Breast Cancer Rehabilitation Summit

28 March 2026

At RRU Seminar Room 7th Floor, Kharghar, Navi Mumbai

Do You Know?

In, 2018, FDA approves larotrectinib, the first drug that targets tumors with NTRK gene fusions.

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Cancer News
Breast cancer study reveals synergistic effect of CDK2 and CDK4/6 combination therapy.

MedicalXpress, 22/01/2026

CDK4/6 inhibitors, combined with endocrine therapy, are the standard first-line treatment for hormone receptor (HR)-positive, HER2-negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops over time...

Cancer might protect against Alzheimer’s — this protein helps explain why?

Nature, 22/01/2026

A study in mice provides a possible molecular solution to the medical mystery: a protein produced by cancer cells seems to infiltrate the brain, where it helps to break apart clumps of misfolded proteins that are often associated with Alzheimer’s disease...

Discovery illuminates how inflammatory bowel disease promotes colorectal cancer.

Eurekalert, 22/01/2026

Neutrophils can promote colorectal tumors by secreting highly reactive molecules that can damage DNA in gut-lining cells. However, the team found that the gut ILC3s also induce a distinctive pattern of gene activity in the neutrophils including increased expressions of genes known to promote tumor...

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